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apalutamide will reduce the level or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication that happen to be CYP3A4 substrates can result in decrease publicity to these medicines.Tolerance to estazolam may build f